Endocrine Abstracts

Cushing’s syndrome is a condition characterized by hypercortisolism (endogenous and exogenous) regardless of its etiology. Hypercortisolism caused by an adrenocorticotropin secreting pituitary adenoma is defined as Cushing’s disease. These tumors represent 10-12% of all pituitary adenomas. ACTH-secreting macroadenomas occur in only 4-23% of all patients with Cushing’s disease. We present the case of 56-year-old female patient with hypercortisolism and stigmata o...

Polycystic ovary syndrome (PCOS) is characterized by excessive androgen secretion and women with PCOS are at risk of developing anxiety disorders. Maternal testosterone levels in humans have been shown to affect brain development and to be correlated to mental function. During pregnancy, women with PCOS display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. This study investigated whether maternal androgen exces...

Introduction: The association between CRP and prediabetes has not been sufficiently investigated. The aim of the study was to determine the association of prediabetes with subclinical inflammation, as well as to examine the correlation of sensitive CRP (hsCRP) with fasting glycemia and 2 h glycemia during exercise during the OGTT test.Methods: The study included 106 patients with angiographically diagnosed coronary artery disease, who, based on the oral ...

Introduction: Secondary failure (SF) of oral therapy in patients with type 2 diabetes is a common clinical phenomenon, which often puts the practitioner in a dilemma as to which therapeutic regimen to choose for continuing therapy. The dilemma primarily applies to patients in whom there is no clear clinical and biochemical evidence of significant insulin deficiency. This is precisely why there has been an increased interest in the use of short-term intermittent insulin therapy...

Introduction: Acromegaly is a chronic disease that occurs as a result of excessive growth hormone secretion, caused by somatotropin-secreting tumors of the pituitary gland in 98% of cases. The first line of treatment for these patients is operative via transsphenoidal approach, however, absolute remission is not achieved in 50% of patients and pharmacological therapy is indicated.Case report: We will present the case of a 43-year-old patient who was hosp...

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...